7-(ALPHA-(2-AMINO-4-THIAZOLYL)-ALPHA-(4-OXO-2-AZETIDINYL-SU-BS TITUTED IMINO)ACETAMIDO)-3-SUBSTITUTED METHYL-DELTA3-CEPHEM-4-CARBOXYLIC ACID AND ITS PRODUCTION

摘要

NEW MATERIAL:A compound shown by the formula I {A is tetrazolylthio shown by the formula II [R1 is H, or (OH-substituted)lower alkyl], pyridino shown by the formula III (R2 and R3 are amino, H, lower alkyl, or lower alkoxy), or lower alkylpyrrolidinio shown by the formula IV (R4 is lower alkyl); B is H, or anion; n is 0-2}. EXAMPLE:(Z)-7-[alpha-(4-Oxo-2-azetidinyloxyimino)alpha-(2-tritylamin-o- 4-thiazolyl) acetamido]-3-(1-methyl-5-tetrazolyl)thiomethyl- DELTA3-cephem-4-carboxylic acid benzhydryl ester shown by the formula V. USE:An antibacterial agent, an additive for feed, or a perservative. PREPARATION:A 3-substituted methyl-DELTA3-cephem-4-carboxylic acid shown by the formula VI (R5 is H, or amino-protecting group; R6 is H, COOH-protecting group) is reacted with an alpha-(4-oxo-2-azetidinyl-substituted imino)thiazolylacetic acid shown by the formula VII (R7 is R5), and optionally deprotected.