PREPARATION OF MINERAL ACID SALT OF ALPHAAHALOGENOOBETAA AMINOPROPIONITRILE

摘要

PURPOSE:To obtain the titled compound in high purity in high yield useful as an intermediate for preparing an alpha-amino acid, by reacting an alpha,beta-dihalogenopropionitrile with ammonia in water and/or an organic solvent, followed by reacting the resulting product with a mineral acid. CONSTITUTION:1Mol alpha-beta-dihalogenopropionitrile is reacted with not less than 2mol ammonia in water and/or an organic solvent (e.g., methanol, ethanol, etc.) at -40-30 deg.C. Formed alpha-halogeno-beta-aminopropionitrile is extracted, and the extracted solution is reacted with a mineral acid (e.g., HCl, H2SO4,etc.) to give a mineral acid of an alpha-halogeno-beta-aminopropionitrile. The reaction may be carried out in air atmosphere, but the reaction in inert gas atmosphere, e.g., N2, etc. preferably prevents side reactions. Ammonia is used as 5-30wt% agueous ammonia or 2-25wt% ammonia in an organic solvent.