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Analogifremgangsmaade for the preparation of 2,6-dimethyl-4- (2,3-dichlorophenyl) -1,4-dihydropyridine-3,5-dicarboxylic acid-3-methylester-5-ethyl ester
Analogifremgangsmaade for the preparation of 2,6-dimethyl-4- (2,3-dichlorophenyl) -1,4-dihydropyridine-3,5-dicarboxylic acid-3-methylester-5-ethyl ester
The present invention relates to new compounds having antihypertensive effect, which compounds are of the formula I, IMAGE (I) wherein R1 is selected from the group consisting of -CH3, -C2H5, -CH2CH2OCH3, and -CH2CH2OC2H5, and R2 is selected from the group consisting of -C2H5, -CH(CH3)2, -C(CH3)3, -CH(CH3)CH2OCH3, C(CH3)2CH2OCH3, and -CH2C(CH3)=CH2, whereby R1 and R2 are not the same, R3 is selected from the group consisting of chloro, and R4 is selected from the group consisting of chloro, and methyl, a method for lowering the blood pressure in mammals including man using said compounds, and pharmaceutical preparations containing said compounds.
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机译：本发明涉及具有抗高血压作用的新化合物，该化合物具有式I，（I），其中R 1选自-CH 3，-C 2 H 5，-CH 2 CH 2 OCH 3和-CH 2 CH 2 OC 2 H 5，并且R 2为选自-C2H5，-CH（CH3）2，-C（CH3）3，-CH（CH3）CH2OCH3，C（CH3）2CH2OCH3和-CH2C（CH3）= CH2，其中R1和R2为另外，R 3选自氯，R 4选自氯和甲基，用于降低包括人在内的哺乳动物的血压的方法，以及使用所述化合物的药物制剂。
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