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The dopamine beta-hydroxylase inhibitors, and process for their preparation as well as compositions containing the inhibitors
The dopamine beta-hydroxylase inhibitors, and process for their preparation as well as compositions containing the inhibitors
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机译:多巴胺β-羟化酶抑制剂及其制备方法以及含有该抑制剂的组合物
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摘要
Compounds of structure (II) …CHEM… in which R is hydrogen or C1-4 alkyl; n is 1 to 5; and R2 to R6 are the same or different and are each hydrogen, halogen, hydroxy, C1-4 alkyl, CN, NO2, SO2NH2, CO2H, CONH2, CHO, CH2OH, CF3, C1-4 alkoxy, SO2C1-4 alkoxy, SO2C1-4 fluoroalkyl or CO2C1-4 alkyl, and pharmaceutically acceptable salts thereof, processes for their preparation, pharmaceutical compositions containing them and their use in therapy as dopamine- beta -hydroxylase inhibitors.
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机译:结构式(II)的化合物……,其中R是氢或C1-4烷基; n为1至5; R 2至R 6相同或不同,分别为氢,卤素,羟基,C 1-4烷基,CN,NO 2,SO 2 NH 2,CO 2 H,CONH 2,CHO,CH 2 OH,CF 3,C 1-4烷氧基, SO 2 C 1-4烷氧基,SO 2 C 1-4氟代烷基或CO 2 C 1-4烷基及其药学上可接受的盐,其制备方法,包含它们的药物组合物及其在治疗中作为多巴胺-β-羟化酶抑制剂的用途。
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