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FOERFARANDE Foer FRAMSTAELLNING AV NYA TERAPEUTISKT ANVAENDBARA 17beta-AMINO-16alpha-HYDROXISTEROIDER AV ANDOSTAN- OCH ESTRANSERIER SAMT AV ENANTIOMERER OCH OCH RACEMAT pharmaceutically GODTAGBARA SYRAADDITIONSSALTER AV industry
FOERFARANDE Foer FRAMSTAELLNING AV NYA TERAPEUTISKT ANVAENDBARA 17beta-AMINO-16alpha-HYDROXISTEROIDER AV ANDOSTAN- OCH ESTRANSERIER SAMT AV ENANTIOMERER OCH OCH RACEMAT pharmaceutically GODTAGBARA SYRAADDITIONSSALTER AV industry
New and pharmacologically useful 17-amino-16-hydroxy-steroids of the androstane and oestrane series are disclosed having the formula I: CHEM and pharmaceutically acceptable non-toxic acid addition salts thereof, wherein: R1 = H or hydrocarbyl of one to six carbon atoms (preferably lower alkyl, such as methyl); R2 = H or hydrocarbyl of one to six carbon atoms (preferably lower alkyl, such as methyl); R3 = a free, esterified or etherified hydroxyl group; ring A inclusive carbon atoms 6 and 9 has one of the following configurations: CHEM in which R4 = a free, esterified or etherified hydroxyl group; R5 = O or H(R7), wherein R7 is a free, esterified or etherified hydroxyl group; R6 = H or methyl; and the dotted lines represent an optional double bond in 4,5- or 5,6-position; as well as the enantiomers and racemates of these steroids. The novel compounds have antiarrhythmic properties.
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机译:公开了具有式I的雄甾烷和oestrane系列的新的且在药理学上有用的17-氨基-16-羟基类固醇及其药学上可接受的无毒酸加成盐,其中:R 1 = H或1至1的烃基。六个碳原子(最好是低级烷基,例如甲基); R 2 = H或1-6个碳原子的烃基(优选低级烷基,例如甲基); R3 =游离的,酯化的或醚化的羟基;含环A的碳原子6和9具有以下构型之一:其中R4 =游离的,酯化的或醚化的羟基。 R5 = O或H(R7),其中R7是游离的,酯化的或醚化的羟基; R 6 = H或甲基;虚线表示在4,5-或5,6-位的任选双键;以及这些类固醇的对映体和外消旋体。新型化合物具有抗心律失常特性。
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