METHOD FOR EXTRACTING INTRAVENOUSLY TOLERABLE GAMMAGLOBULINS.

摘要

1495159 Gamma globulin PLASMESCO AG 29 Dec 1975 [2 Jan 1975] 53020/75 Heading A5B [Also in Division C3] The compatability of gamma globulin precipitated from blood or blood products is improved by dissolving the precipitated gamma globulin in an aqueous solution containing from 1 to 30% of a hydroxyethyl starch having a molecular weight of 1000 to 900000 and thereafter recovering the gamma globulin from this solution. In an example gamma globulin precipitate is dissolved in a buffered aqueous solution at pH 6.7 in a concentration of about 6%. About 10% of hydroxyethyl starch (M.W. 1000 to 900000) is added to this solution which facilitates separation of existing gamma globulin aggregates and simultaneously protects non-aggregated gamma globulin molecules. After addition of 10% of polyethyleneglycol the mixture is centrifuged. The remaining supernatant phase is mixed with 20% polyethylene glycol at pH 7.2 and centrifuged. The resulting precipitate is taken up in saline solution and is suitable for the therapeutic use.