Antigen obtained from human tissue, a process for using the antigen to prepare monoclonal antibodies for the diagnosis and treatment of cancer, method for detecting cancer, as well as antibodies to the antigen

摘要

A novel tumour-associated antigen expressed by colon carcinoma is disclosed. The antigen, characterized by monoclonal antibody YCR010, is an O-linked glycoprotein having a molecular weight in the range of about 36,000 to about 39,000 and an isoelectric point within the range of about 5.1 to about 5.4. Antibodies directed against the antigen, methods for their production and diagnostic and therapeutic uses therefore are provided.