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Improvements in the object of Invention Patent 529608 which concerns process obtaining new derivatives of 1H-imidazol
Improvements in the object of Invention Patent 529608 which concerns process obtaining new derivatives of 1H-imidazol
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机译:对发明专利529608的目的的改进,该发明专利涉及获得1H-咪唑的新衍生物的方法
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摘要
Process for obtaining 1H-imidazole derivatives of general formula I": comprising the reaction of a compound of formula II where A is methine (-CH-) with a compound of formula III" where X is bromine or chlorine, R"' is a halogen atom selected from chlorine or fluorine in any of the 5 or 7 positions of the benzo[b]thiophene residue and joining the methylene group (-CH2-) to the benzo[b]thiophene residue in the 2 or 3 position thereof, in hexamethyl phosphorotriamide, in the presence of a mineral base, preferably sodium hydride, and at a temperature of between 0 degree C and 100 degree C for a period of time of between 1 and 24 hours, with purification by crystallization or extraction, washing, drying and chromatography, yielding addition salts by treatment with the corresponding acids. IMAGE
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