A process for preparing novel derivatives of 1,3-dihi-dro-6-1-cyano-1-isopropyl-n-phenethyl-N-methyl-omega-aminoalkyl quil-7 - hydroxy-furo (3,4 c) -pyridine

摘要

This invention relates to new 1,3-dihydro-6-[1-cyano-1-isopropyl-N-phenethyl-N-methyl- omega -aminoalkyl]-7-hydroxy-furo-(3,4-c)-pyridine derivatives of the general formula IMAGE wherein each of A1 and A2 independently represents various substituents and to pharmaceutically acceptable salts of said derivatives, to a process for the preparation of the same, comprising reacting, in stoichiometric proportions, at 15 DEG -65 DEG C., in dimethylsulphoxide, a 6-(1-cyano-2-methyl-propyl)-7-hydroxy-furo-(3,4-c)-pyridine derivative with the appropriate N-methyl-N-phenethyl- omega -aminoalkyl choride and, finally, to a therapeutic composition of matter comprising as an essential ingredient therein any of said compounds in an amount effective to act as a calcium antagonist or a serotonin antagonist together with an appropriate diluent or carrier.