Antagonists of the antidiuretic and/or vasopressor action of arginine vasopressin.

摘要

PROCEDURE FOR OBTAINING A PEPTIDE COMPOUND TO ANTAGONIZE THE ANIMAL RESPONSE, IN VIVO, TO THE ANTIDIURETIC ACTION OF AN ANTIDIURETIC HORMONE. CONSISTS OF: A) TREATING BY SOLID PHASE SYNTHESIS BOC-GLY-RESIN AND NEUTRALIZATION AND COUPLING WITH AN AMINO-ACID, TO PRODUCE BOC-PHE-VAL-ASN-CY (BZL) -W- (DOL) -ARG (TOS -GLY-RESIN); B) TREAT THE PREVIOUS COMPOUND IN A DEPROTECTION CYCLE, NEUTRALIZE IT AND COUPLING IT WITH BOC-X TO PRODUCE TERT-BUTOXICARBONIL-OCTAPEPTIDIL RESIN OF FORMULA BOC-X-PHE-VAL-ASN-CY (BZL) -C-B)) (TOS-GLY-RESINA); C) AMMONOLIZE THE COMPOUND OBTAINED IN B) TO OBTAIN A COMPOUND OF FORMULA BOC-XPHE-VAL-ASN-CY (BZL) -W- (D- O L -) - ARG (TOS) -GLY-NH2; D) CONVERT THE COMPOUND OBTAINED IN C) INTO A COMPOUND OF FORMULA (II); AND E) CONVERT THE COMPOUND D) INTO A PEPTIDE OF FORMULA (I). (Machine-translation by Google Translate, not legally binding)