MONOCLONAL ANTIBODY HAVING SPECIFITY FOR DOUBLE-STRANDED CONFORMATION OF NATIVE DNA

摘要

Described are monoclonal antibodies having conformation-dependent specificity for native dsDNA, as exemplified by the IgM antibody produced by murine hybridoma ATCC No. HB 8329, have been prepared. These antibodies may be bound to double-stranded DNA to form immune complexes and thus are useful in immunodiagnostic tests to detect DNA duplex formation by DNA hybridization and to separate dsDNA from a solution containing it.