BENZOPYRANO 4,3-C PYRAZOLES AND PYRAZOLO 4,3-C QUINOLINES

摘要

This invention provides a benezene-fused heterocyclic compound of the formula: IMAGE wherein R1 is halogen, nitro, amino, hydroxy, lower alkyl, lower alkoxy substituted by carboxy or protected carboxy, acylamino which may have lower alkyl on the amino moiety, or aryloxy which may have halogen, R2 is hydrogen or halogen, X is -O- or IMAGE in which R3 is hydrogen, lower alkyl or acyl and A is a group of the formula: IMAGE in which R4 is hydrogen, lower alkenyl, lower alkynyl or alkyl which may have suitable substituent(s) selected from the groups consisting of hydroxy, acyl, lower alkoxy, di(lower)alkylamino, carboxy, protected carboxy and aryl; or R1 is hydrogen or lower alkoxy, R2 is hydrogen, X is IMAGE in which Ra3 is lower alkanoyl and A is a group of the formula: IMAGE and pharmaceutically acceptable salts thereof. This compound possesses diuretic activity, uricosuric activity and vasodilative activity and are useful as a diuretic agent, uricosuric agent and anti-hypertensive agent. The invention further relates to processes for the preparation of this compound and pharmaceutical composition comprising compound of the above formula.