Pulverized mixture of lipid and hydrophobic constituents, process for preparing them, hydrated lipid lamellar phases and process for preparing them, pharmaceutical or cosmetic compositions containing hydrated lamellar lipid phases

摘要

The invention relates to a method for preparing a pulverulent mixture of amphiphilic lipidic constituents and possibly of hydrophobic constituents, as well as to a method for producing hydrated lipidic lamellar phases from the pulverulent mixture. The method comprises dissolving the amphiphilic lipidic constituents and the hydrophobic constituents in an appropriate solvent and then atomizing said solution in a flow of gaseous fluid to produce the pulverulent mixture. The mixture thus obtained is a homogeneous and very fine powder which can be very easily dispersed in a suitable aqueous dispersion medium to produce either slightly hydrated lipidic lamellar phases or highly hydrated lipidic lamellar phases such as liposomes useful in the pharmaceutical and cosmetic fields.