Process for the peparation of 3-acylamino-4-alkoxy-phenyl-beta-hydroxysulfones and -sulfone - sulfuric acid esters

摘要

Process for the preparation of 3- (acyl) amino-4-alkoxy-phenyl-β-hydroxyethylsulfone (sulfuric acid esters) of the formula (1) IMAGE in which R1 is alkyl of 1-4 C atoms, R2 is hydrogen or one of the groupings IMAGE, with the proviso that n = 1 when R2 = H and n = 0 when R2 = acyl by using 2-alkoxyacylanilines of the formula (2) IMAGE wherein R1 and R2 are the have the meanings mentioned, in a known manner to the corresponding sulfochlorides substituted in the p-position to the alkoxy group, the latter with alkali metal or ammonium sulfite in aqueous medium at pH 7.0-8.5 and at -5 to + 40 ° C. to the corresponding Reduced sulfinates, these alkoxylated with ethyl oxide in aqueous medium at pH 6.0-8.5 and 40-80 ° C. to give the 3- (acyl) amino-4-alkoxyphenyl-β-hydroxyethyl sulfones of the formula (1) (with R2 = Acyl and n = O) and these, if appropriate, are esterified with conc. Sulfuric acid at 70-150 ° C to the compounds of formula (1) (with R2 = H and n = 1).