STABLE COMPOSITION FOR LOCAL CORTICOTHERAPY CONTAINING HYDROCORTISONE IN THE SOLUBILIZED CONDITION.

摘要

Stable compositions for local corticotherapy contain, in the solubilised state, hydrocortisone in at least one solubilising agent which is: (i) caprolactam as an at least 30% by weight solution in an aliphatic alcohol having 2 to 12 carbon atoms, (ii) 2- isostearyl-1-hydroxyethyl-1- benzylimidazolinium chloride as an at least 25% by weight solution in water or (iii) an alkylphenol polyglycerol corresponding to the following formula: R- O &lsqbstr& C2H3(CH2OH)-O &rsqbstr& n-H in which R represents an octylphenyl or nonylphenyl radical and n is an integer from 4 to 10, preferably 6.