process for the production of sterile, crystalline cefalotinnatrium, cefaloridinbetain or cefazolinnatrium

摘要

Sterile, essentially crystalline cephalosporins for parenteral administration are prepared by a freeze-drying process wherein, after rapidly cooling a solution of such cephalosporins to at least -15° C. in no more than 3 hours, the frozen solution is held between about 0° C. and about -10° C. until the nucleation of the cephalosporin is substantially complete before subjecting said frozen solution to a high vacuum and a moderate amount of heat to sublime the water therefrom.