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New diphosphonic acids, their salts, their process of preparation and their application of international application no.
New diphosphonic acids, their salts, their process of preparation and their application of international application no.
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机译:新的二膦酸,其盐,其制备方法及其在国际申请中的应用
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摘要
Biphosphonic acids of general formula I: IMAGE (I) in which R is a fluorine atom of a linear or branched alkyl radical containing between 1 and 5 carbon atoms, which may also be substituted by one or more amino groups of fluorine atoms or both amino groups and fluorine atoms, R' is hydroxy or fluorine, and their salts with an alkali metal, an organic base or a basic aminoacid, exhibit valuable properties in the treatment of urolithiasis or in the treatment as inhibitors of bone reabsorption. The compound 4-amino-1-hydroxybutan-1,1-biphosphonic acid is between 100 and 300 times more active than Cl2MDP.
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