ASUKAMYCIN DERIVATIVE, SYNTHESIS THEREOF AND CARCINOSTATIC AGENT

摘要

NEW MATERIAL:A compound expressed by formula I (R1 is amoinocarbonyl; R2 is H or tert-butyloxycarbonyl; R3 is H or two R3 groups together form isopropylidene, provided that R1 will not represent L-alanyl). EXAMPLE:N6-tert-Butyloxycarbonyl-2-chloro-9-[5'-O-(N-tertbut yloxycarbonyl-L- phenylalanyl)sulfamoyl-beta-D-ribofuranosyl]adenine. USE:A carcinostatic agent. PREPARATION:A compound expressed by formula II, e.g. N6-tert-butyloxycarbonyl-2-chloro-9-(2',3'-O-isopropylidene-5'-O-sul famoyl-beta-D-ribofurano syl)adenine, is reacted with di-tert-butyl dicarbonate to give a compound expressed by formula III, which is then reacted with an active ester of an aminocarboxylic acid (without including L-alanine).