METHOD OF DETECTING ABNORMAL CONTENT OF GADOLINIUM (GD) OF NUCLEAR FUEL PELLET

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  机译： 检测核燃料球粒中GD含量异常的方法

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  机译： 核燃料球粒中G含量的测定方法

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  机译： 核燃料丸中OF含量的测定方法

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• 1. BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 （HMGB1） is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS： Sixty rats were randomly divided into a normal control group （group A, n=10） anda Vibrio vulnificus sepsis group （group B, n=50）. Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus （concentration 6×108 cfu/mL, volume 0.1 mL/100g）） into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance（ANOVA） and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS： Compared to group A （0.652±0.177）, HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour （1.161±0.358, P=0.013）, 24 hours （1.679±0.235, P=0.000）,and 48 hours （1.258±0.274, P=0.004） （P〈0.05）, and peaked at 24 hours. Compared to group A（0.594±0.190）, HMGB1 protein expression at 6 hours （1.408±0.567, P=0.026） after infection wassignificantly increased （P〈0. 05）, and peaked at 24 hours （2.415±1.064, P=0.000） after infection.Compared to group A （0.699±0.054）, lung water content was significantly increased at 6 hours（0.759±0.030, P=0.001）,12 hours （0.767±0.023, P=0.000）, 24 hours （0.771±0.043, P=0.000） and 48hours （0.789±0.137, P=0.000） after infection （P〈0.05）. Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION： Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis. [J] . Qiao-meng Qiu ,Zhong-wang Li ,Lu-ming Tang . 世界急诊医学杂志(英文) . 2011,第4期
• 2. An Integrated Process for Recycling of ThOsub2/subBased Mixed Oxide Rejected Nuclear Fuel Pellets [J] . Gitender Singh ,Prashal M. Khot ,Pradeep Kumar . 核科学与技术国际期刊（英文） . 2017,第4期
• 3. Thermal Conductivity Measurement of Zr-ZrOsub2/subSimulated Inert Matrix Nuclear Fuel Pellet [J] . Dong-Joo Kim ,Young Woo Rhee ,Jong Hun Kim . 核科学与技术国际期刊（英文） . 2013,第2期
• 4. FERROMAGNETIC　INTERACTION　BETWEEN　GADOLINIUM（Ⅲ）　AND　COPPER　（Ⅱ）IONS　IN　N，N＇－BIS（2－AMINOPROPYL）OXAMIDO　COPPER（Ⅱ）　BRIDGED　BINUCLEAR　Gd（Ⅲ）－Cu（Ⅱ）　COMPLEX [J] . Yan Tuan LI ,Dai Zheng LIAO ,Zong Hui JIANG . 中国化学快报：英文版 . 1994,第8期
• 5. PIXE方法应用于中医中药中重金属含量定量检测方法研究 [C] . 傅云清 ,张斌 . 第六届全国核技术及新技术在中医中药中研究与应用学术交流会 . 2015
• 6. 核燃料棒Gd2O3含量无损检测装置研制 [A] . 王德军 . 2015