procedure for exposure of an epitope of a protein with specific polypeptidstruktur, and vectors for use in the procedure hybridproteiner comprehensive epitopen,and the use of hybridproteinet by diagnoses.

摘要

The invention relates to a procedure for the incorporation of a DNA sequence coding for a peptide immunogen into a DNA vector. This procedure includes the cleavage of the DNA vector at distinct sites, preferably in a random manner, the recombination of the different fragments with the sequence coding for the protein, the transformation of competent cells with the series of the combined fragments, the detection and isolation of those cell colonies which express the products recognized by antibodies to the peptide immunogen.