bicyclic aromatic derivatives, their manufacture and their use in human and veterinary medicinal and cosmetic purposes

摘要

Bicyclic aromatic compound having the formula IMAGE (R) wherein R1, R2, R3 and R4 represent hydrogen or alkyl, at least two of R1-R4 radicals being other than hydrogen, A represents methylene or dimethylene; when A represents dimethylene, R1 and R3 together can form a methylene or dimethylene radical, R5 and R6 represent hydrogen, halogen, lower alkyl, lower alkoxy or hydroxy, R' represents hydrogen, hydroxy, alkoxy, C1-C4 cicyloxy or amino, R'' represents hydrogen or lower alkoxy, or R' and R'' together form an oxo, methano or hydroxyimino radical, B represents cyclohexyl, cyclohexenyl, cyclohexadienyl or phenyl, substituted or not, R represents -CH2OH or -COR7, R7 represents hydrogen, -OR8 or IMAGE R8 represents hydrogen, C1-C20 alkyl, monohydroxyalkyl, polyhydroxyalkyl, aryl, aralkyl or a sugar residue. r' and r'' represent hydrogen, alkyl, monohydroxyalkyl, polyhydroxyalkyl, aryl or benzyl, the residue of an amino acid or an aminated sugar, or taken together form a heterocycle, and the salts of the compound of formula I and their optical isomers as well as the tautomeric forms of the compounds of formula I with the exception of 2-[(5,8-methano-5,6,7,8-tetrahydro-2-naphthyl) carbonyl] benzoic acid. The compounds are useful in the treatment of the hair and skin having an oily appearance.