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PROCESS FOR PRODUCING 20-SPIROXANE DERIVATIVES AND OPENED ANALOGUES THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AS ACTIVE AGENTS
PROCESS FOR PRODUCING 20-SPIROXANE DERIVATIVES AND OPENED ANALOGUES THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AS ACTIVE AGENTS
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机译:制备20-螺恶烷衍生物的过程及其类似物和包含它们作为活性剂的药物组合物的公开说明
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摘要
Steroid compounds of the 20-spiroxane series and their analogues having an open ring E of the formula, IMAGE (I) in which -A-A- represents the group -CH2-CH2- or -CH=CH-, R1 represents hydrogen, and R2 represents an alpha -oriented lower alkoxycarbonyl radical, or R1 and R2 together represent an alpha - or a beta -oriented methylene radical, -B-B- represents the group -CH2-CH2- or an alpha - or beta -oriented group IMAGE X represents two hydrogen atoms or oxo, Y1 and Y2 together represent the oxygen bridge -O-, or Y1 represents hydroxy, and Y2 represents hydroxy, lower alkoxy or, if X represents H2, also lower alkanoyloxy, and salts of compounds in which X represents oxo and Y2 represents hydroxy, are distinguished as effective aldosterone-antagonists with minimal side-effects and, for that reason, are especially suitable for the treatment of all forms of hyperaldosteronism.
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