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PROCESS FOR PRODUCTION OF DERIVATIVES OF NEW DELTA ABOVE H AND DELTA ABOVE S ANDROSTENE AND MEDICAL PREPARATIVES CONTAINING THEREOF
PROCESS FOR PRODUCTION OF DERIVATIVES OF NEW DELTA ABOVE H AND DELTA ABOVE S ANDROSTENE AND MEDICAL PREPARATIVES CONTAINING THEREOF
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机译:H以上和δ以上的新衍生物的制备方法及包含该衍生物的药物制剂
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摘要
The invention relates to novel steroids having the formula: IMAGE wherein X=CH2-S-R3 or S-S-R4; R1=O or H ( beta R5); R2=O or H ( beta R6); R3=H, acyl (1-18C) or alkyl (1-4C); R4=H, acyl (1-18C) or hydrocarbyl (1-18C), the acyl or hydrocarbyl group being optionally substituted; R5=OH, O acyl (1-18C) or an ether group; R6=OH, O acyl (1-18C) or an ether group; and the dotted lines represent a carbon-carbon bond in 4,5- or 5,6 position; to processes for their preparation and to pharmaceutical compositions containing these steroids as active constituents. The novel compounds possess particularly aromatase-inhibiting properties.
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