A process for the preparation of pharmaceutically active N-acylated L-TRIPTOFAN DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND A PHARMACEUTICAL PRODUCT CONTAINING THEM, APPLICABLE TO RELIEVE PAIN IN HUMAN BEINGS

摘要

N-acylated derivatives of L-tryptophan of general formula (I), IMAGE (I) in which R is selected from the group consisting of: (a) a phenyl group, mono-substituted or di-substituted in the meta and para positions with halogens, linear or branched alkyl groups containing from 1 to 9 carbon atoms, the cyano group or the trifluoromethyl group, (b) a benzyloxy group, mono-substituted or di-substituted in the meta and para position with substituents selected from those indicated at (a), and (c) a benzydryloxy group. The derivatives are used in therapy, particularly for human pain relief, in the treatment of pathological conditions of the central nervous system and of pathological intestinal conditions.