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METHOD OF INCREASING THE EFFECTIVENESS OF A B-LACTAM ANTIBIOTIC USING PENCILLANIC ACID 1,1-DIOXIDE OR AN ESTER THEREOF
METHOD OF INCREASING THE EFFECTIVENESS OF A B-LACTAM ANTIBIOTIC USING PENCILLANIC ACID 1,1-DIOXIDE OR AN ESTER THEREOF
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机译:用戊酸1,1-二氧化物或其酯提高B-内酰胺类抗生素药效的方法
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摘要
1,1-Dioxides of penicillanic acid and esters are described which are useful as beta -lactamase inhibitors. These compounds are 1,1-dioxides of penicillanic acid and of corresponding esters which are easily hydrolysable in vivo, derivatives of penicillanic acid 1,1-dioxide, the carboxyl radical of which is protected by a standard protective group of the carboxyl radical of penicillins, which are useful intermediates for the synthesis of penicillanic acid 1,1-dioxide, and 1-oxides of penicillanic acid and of certain of its esters which are useful as chemical intermediates for the synthesis of penicillanic acid 1,1-dioxide and of its esters. These 1,1-dioxides of penicillanic acid and esters are antibacterial agents, also capable of increasing the effectiveness of various antibiotics of the beta -lactam type with respect to bacteria which produce beta -lactamase.
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