New N-substd.-L-prolyl-L-vaginal derivs. - useful as potent inhibitors of human leukocyte elastase

摘要

Proline derivs. of formulae (I)-(III) and their acid- and base-addn. salts and equilibrium addn. cpds. of the CHO gp., R1, R5, R9=3-6C alkyl R2, R3, R6, R7, R10=1-10C alkyl opt. substd. by monocyclic aryl or by an amide, urea or carbamate gp. via the N atom R4, R11=1-6C alkyl or 1-6C alkoxy both opt.substd. or mono-or bi-cyclic aryl R8=OH, 1-6C alkoxy or 7-12C aralkoxy. The CHR2, CHR3, CHR6, CHR7, CHR10 and the proline gp. are of the L-configuration.