A process for preparing compounds related to espergualina

摘要

Preparation of espergualina Derivatives of formula (i) wherein R1 is a Lower alquileno replaced or not with a hydroxymethyl; X is H or Halogen, M and N are integers between 1 and 5, and its Salts.Are obtained by separation of the protective groups, other espergualina protected Derivative of formula (ii), where RK1 is a alquileno Lower linear chain or branched, substituted or not with a hydroxymethyl Group; R2 is a protective Group of amino; R3 is a protected amino Group and X, and M N are defined above.The Protecting groups can be separated by catalytic reduction with Palladium Black or by Treatment with Trifluoroacetic acid and cf3so3 HBR or hydrolysis with acetic acid to 0 - 50jc. These compounds are stable in aqueous solutions, inhibiting the development of micro-organisms Gam and positive and negative are antitumor agents.