CHLORHEXIDINE MONOPHOSPHANILATE AND PROCESS FOR SELECTIVELY PREPARING PHOSPHANILATE ACID SALTS OF CHLORHEXIDINE

摘要

0244HAbstract of the DisclosureA water soluble salt of chlorhexidine is mixed with a watersoluble salt containing phosphanilate mono-anion when chlorhexidinediphosphanilate is desired, or with a water soluble salt containingphosphanilate di-anion when chlorhexidine monophosphanilate isdesired. The desired mono- or di-phosphanilate salt of chlorhexidineprecipitates and is selectively recovered. Chlorhexidine monophos-phanilate is a novel salt having antibacterial activity substantiallycomparable to that of chlorhexidine diphosphanilate.