DERIVATIVES OF BICYCLIC AMINOACIDS, PROCESSES FOR THEIR PREPARATION, AGENTS CONTAINING THESE DERIVATIVES AND THEIR USE AND NEW BICYCLIC AMINOACIDS AS INTERMEDIATES AND PROCESSESFOR THEIR PREPARATION

摘要

- 1 -HOE 82/F 054Abstract of the disclosure:The invention relates to compounds of theformula I(I)in whichn denotes 0 or 1,R denotes hydrogen, alkyl or aralkyl, R1 denoteshydrogen or alkyl, which can optionally be substituted byamino, acylamino or benzoylamino, alkenyl, cycloalkyl, cyclo-alkenyl, cycloalkylalkyl, aryl or partially hydrogenatedaryl, which each can be substituted by alkyl, alkoxy orhalogen, arylalkyl or aroylalkyl, both of which can be sub-stituted in the aryl radical as defined in the aforegoing,a monocyclic or bicyclic sulfur or oxygen and/or nitrogenheterocyclic radical, or a side chain of a naturallyoccurring aminoacid, R2 denotes hydrogen, alkyl, alkenylor arylalkyl, Y denotes hydrogen or hydroxyl, Z denotes- 2 - HOE 82/F 054hydrogen or Y and Z together denote oxygen and X denotesalkyl, alkenyl, cycloalkyl, aryl, which is monosubstituted,disubstituted or trisubstituted by alkyl, alkoxy, hydroxyl,halogen, nitro, amino, alkylamino, dialkylamino or methylene-dioxy or 3-indolyl,and their physiologically acceptable salts, pro-cesses for their preparation, agents containing these andtheir use as medicaments and also bicyclic amino acids astheir intermediates and processes for their preparation.