PHARMACEUTICAL COMPOSITION FOR CHANGING CALCIUM FLUX ACROSS CELLULAR MEMBRANES, COMPRISING ABSCISCIC ACID

摘要

Pharmaceutical compositions useful in regulating calcium transport across cellular membranes in man and animals are disclosed. The compositions contain plant growth regulators such as abscisic acid and its derivatives. In particular, the compositions contain a compound of the formula: CHEM or R1 - Y - R2 wherein R1 is an alkyl of up to seven carbons or a saturated or unsaturated six membered carbon ring, which may be substituted; R2 is a cyano group, a thio or hydroxy lower alkyl group or a group containing a carbonyl, most commonly a carboxyl group; R3 is hydrogen or lower alkyl; R4 is hydrogen, lower alkyl or halide; R5 is hydrogen or hydroxy; R6 is hydrogen, carboxy or carboxy lower alkyl, or R5 and R6 form a bond between the carbons to which they are attached or with the carbons to which they are attached form a carbon ring; or R2 and R6 together with the carbon to which they are bonded form a heterocyclic ring; n is 0 or 1, with the proviso that when n is 0, R2 is an acyl group; X is -CH2-, -CH=CH-, -CH2-CH2-, -CH2-NH-, -CH2-O-, -CH2-S- or -NH-CO-; and Y is a carbocyclic group bonded to R1 and R2 through a single carbon. The compositions are formulated for oral, parenteral or other form of administration in dosages necessary to effect the desired change in calcium flux. Daily doses of 0.01 to 200 mg/kg in one or more doses are contemplated. Dosage units may be formulated with any pharmaceutically acceptable carrier which is compatible with the active ingredient.