Fluorine derivatives of vitamin D3 and cell differentiation-inducing agents containing the same as an active ingredient

摘要

Described are novel compounds of the formula (IV)wherein R₁ is a hydrogen atom, a nyaroxyl group or a protected hydroxyl group and R₂ is a hydrogen atom or a protecting group,a pharmaceutical composition useful as a cell differentiation-inducing agent, which contains an effective amount of a compound of the formula IV (wherein R₂ is H) as an active ingredient and a pharmaceutically acceptable carrier or diluent,a method of inducing cell differentiation by administering an effectiveamount of a compound of the formula IV (wherein R₂ is H to a patient,and a proceesfor producing a compound of the formula (IV) by subjecting a previtamin D₃ derivative of the formula (III)wherein R₁ and R₂ are as defined above, to thermal isomerization to yield a vitamin D₃ derivative of the formula (IV) mentioned above.