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Process for making a targeted cell susceptible to lysis by cytotoxic T lymphocytes
Process for making a targeted cell susceptible to lysis by cytotoxic T lymphocytes
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机译:使靶细胞易于被细胞毒性T淋巴细胞裂解的方法
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摘要
A process whereby any cell can be made susceptible to lysis by cytotoxic T lymphocytes is disclosed. The process consists of binding or chemically linking an antibody, specific for portions of a T lymphocyte receptor shared by most cytotoxic T lymphocytes or a receptor-associated molecule, to the surface of the targeted cell. Recognition of or interaction with the reactive site of the antibody by the T lymphocyte results in lysis of the targeted cell. The antibody to the T lymphocyte receptor or associated molecule may be bound directly to the targeted cell using a crosslinking reagent or indirectly by means of a molecule such as an antibody, a hormone, or a carbohydrate which binds to particular molecules on the targeted cell's surface.
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