Use of azabicloalkylbenzamides in the treatment of gastrointestinal motility disorders, migraine, emesis, cluster headaches, trigeminal neuralgia and arrhythmia

摘要

A method of treatment of undesirable actions of 5-HT on the gastro-intestinal tract; migraine, cluster headaches and trigeminal neuralgia, cytotoxic agent or radiation induced nausea and vomiting and/or arrhythmia in mammals, including humans, which method comprises administering an efffe- ctive amount of a compound of formula (I) or a pharmaceutic- allv acceptable salt thereof:wherein:R is amino or C_1-7 acylamino;X is chloro, bromo or C_1-6 alkylthio; andp is 0 or 1; novel compounds within formula (I)wherein X is bromo or C,.₆ alkylthio, a process for their preparation and their use as pharmaceuticals.