Pyrimido5,4-b1,4oxazine derivatives, process for their preparation, medicament containing them and intermediate pyrimido5,4-b1,4oxazine derivatives

摘要

The invention relates to pyrimido [5,4-b] [1,4] oxazine derivatives of the general formula wherein R, is an alkyl radical, R ₂ is a hydrogen atom, a halogen atom, an azido group, a hydrazino group or a residue of the general formula in which latter R ₅ represents a hydrogen atom, an optionally substituted alkyl radical or benzyl radical and R ₆ represents a hydrogen atom, an amino group, a cycloalkyl group, an optionally substituted phenyl or phenoxy radical or an optionally substituted alkyl radical or R ₅ and R ₆ together with the nitrogen atom to which they are attached form an optionally substituted, represent 6-membered saturated heterocyclic radical, R ₃ and R ₄ independently represents a hydrogen atom or an alkyl radical and R ₉ is a hydrogen atom, an optionally mono-substituted by an oxo group, a cyano group, an aminocarbonyl radical, an alkoxycarbonyl group, a pyridyl group, a Morpholinylcarbonylrest or a phenyl radical or by 1 or more hydroxy group (s) substituted means alkyl, as well as their acid addition salts.; Furthermore, the invention relates to a process for preparing these compounds and pharmaceutical compositions containing them and intermediates for the preparation of the former.