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Use of basic inorganic salts of magnesium or calcium for the stabilisation of benzimidazole derivatives
Use of basic inorganic salts of magnesium or calcium for the stabilisation of benzimidazole derivatives
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机译:镁或钙的碱性无机盐用于稳定苯并咪唑衍生物的用途
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摘要
The pharmaceutical composition of the invention, which comprises a benzimidazole compound of the formula wherein R¹ is hydrogen, alkyl, halogen, cyano, carboxy, carboalkoxy, carboalkoxyalkyl, carbamoyl, carbamoylalkyl, hydroxy, alkoxy, hydroxyalkyl, trifluoromethyl, acyl, carbamoyloxy, nitro, acyloxy, aryl, aryloxy, alkylthio or alkylsulfinyl, R² is hydrogen, alkyl, acyl, carboalkoxy, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, alkylcarbonylmethyl, alkoxycarbonylmethyl or alkylsulfonyl, R³ and R⁵ are the same or different and each is hydrogen, alkyl, alkoxy or alkoxyalkoxy, R⁴ is hydrogen, alkyl, alkoxy which may optionally be fluorinated, or alkoxyalkoxy, and m is an integer of 0 through 4, and a basic inorganic salt of magnesium and/or a basic inorganic salt of calcium, is physically stable.
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机译:本发明的药物组合物,其包含下式的苯并咪唑化合物 <图像文件=“ IMGA0001.GIF” he =“ 41” id =“ ia01” imgContent =“ chem” imgFormat =“ GIF” wi =“ 95” /> Chemistry>其中R¹是氢,烷基,卤素,氰基,羧基,碳烷氧基,碳烷氧基烷基,氨基甲酰基,氨基甲酰基烷基,羟基,烷氧基,羟烷基,三氟甲基,酰基,氨基甲酰氧基,硝基,酰氧基,芳基,芳氧基,烷硫基或烷基亚磺酰基,R 2是氢,烷基,酰基,碳烷氧基,氨基甲酰基,烷基氨基甲酰基,二烷基氨基甲酰基,烷基羰基甲基,烷氧基羰基甲基或烷基磺酰基,R 3和R 4相同或不同,并且各自为氢,烷基,烷氧基或烷氧基烷氧基,R 4为氢,烷基,可任选被氟化的烷氧基或烷氧基烷氧基, m为0至4的整数,并且镁的碱性无机盐和/或钙的碱性无机盐是物理稳定的。
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