2',4'-DIFLUORO-4-HYDROXY-(1,1'-DIPHENYL)-3-CARBOXYLIC DERIVATIVES OF N-ACETYLCYSTEINE AND OF S-CARBOXYMETHYLCYSTEINE HAVING ANTI-INFLAMMATORY AND MUCOLYTIC ACTIVITY, PROCESS FOR THEIR PREPARATION AND RELATED PHARMACEUTICAL COMPOSITIONS

摘要

Some novel 2 min -4 min -difluoro-4-hydroxy-(1,1 min -diphenyl)-3-carboxylic derivatives of N-acetylcysteine and of S-carboxy methylcysteine are endowed with anti-inflammatory, analgesic and anti-pyretic activity combined with mucolytic properties, as well as with toxicologic and pharmacokinetic characteristics such as to be proposed as agents useful in the therapy of the catarrhal diseases of the tracheo-bronchial tract. Some compounds, moreover, are adapted for use by different administration routes, including the aerosol and rectal one, owing to the lack of local irritating effects.