Optically active 2 - (chlorine) - 12 - (3 - (dimethylamino) - 2 - (methyl) - propyl) - 12h - dibenzo (d, g) (1,3,6) dioxazocine as well as their acid-addition salts, to processes for their preparation and pharmaceutical compositions containing these compounds

摘要

The invention relates to optically active 2-chloro-12-(3-dimethylamino-2-methylpropyl)-12H-dibenzo[d,g][1,3,6]di oxazocine of the Formula IMAGE (I) and pharmaceutically acceptable acid additional salts thereof. The enantiomers are especially active against Parkinsion's disease. The optically active enantiomers are prepared by (a) resolving the racemic 2-chloro-12-(3-dimethylamino-2-methylpropyl)-12H-dibenzo[d,g][1,3,6]-d ioxazocine with a optically active organic acid and separating the enantiomers; or (b) dissolving the racemic 2-chloro-12-(3-dimethylamino-2-methylpropyl)-12H-dibenzo[d,g][1,3,6]-d ioxazocine in an organic solvent, crystallizing and isolating one of the enantiomers, optionally dissolving additional racemic 2-chloro-12-(3-dimethylamino-2-methylpropyl)-12H-dibenzo[d,g][1,3,6]-d ioxazocine in the mother liquor obtained and crystallizing and isolating the other enantiomer, and, if desired, repeating the whole process.