PROCESS FOR PREPARING 2-HALO-NICERGOLINE DERIVATIVES AND THEIR ADDITION SALTS WITH ACIDS AND NEW 2-HALONICERGOLINES, COMPOSITIONS COMPRISING 2-HALONICERGOLINES AND PROCESS FOR PREPARING THE SAME

摘要

THE INVENTION CONCERNS A NEW PROCESS FOR THE PREPARATION OF PARTLY NEW 2-HALONICERGOLINE DERIVATIVES. /P P IT CONSISTS OF ESTERIFYING A 2-HALO-1-METHYL-LUMILYSERGOL OF FORMULA (II): BR/ (CF DRAWING IN BOPI) BR/ IN WHICH X REPRESENTS AN ATOM OF CHLORINE, BROMINE OR IODINE OR ITS ADDITIONAL SALT WITH AN ACID AND, POSSIBLY TO CONVERT THE DERIVATIVE OF 2-HALONICERGOLINE THUS OBTAINED INTO A SALT OF ADDITION WITH AN ACID. /P P THE COMPOUNDS OF THE INVENTION IMPROVES THE COGNITIVE FUNCTION OF THE BRAIN AND SHOWS ANTIHYPOXIC ACTION, A-ADRENERGIC BLOCKING ACTION AND AN ANTAGONISM ACTION WITH CALCIUM. / P P THE INVENTION ALSO CONCERNS PHARMACEUTICAL COMPOSITIONS CONTAINING A 2-HALONICERGOLINE.