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Site-specific chiral ruthenium (II) and cobalt (III) antitumor agents
Site-specific chiral ruthenium (II) and cobalt (III) antitumor agents
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机译:特定部位的手性钌(II)和钴(III)抗肿瘤药
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摘要
This invention concerns a coordination complex of the formula (R).sub. 2 --M--(Y).sub.2 wherein M comprises a suitable transition metal, e.g. cobalt or ruthenium, R comprises 1,10-phenanthroline or a substituted derivative thereof, Y comprises a labile ligand, e.g. chloride, tartrate, malonate or ascorbate ion and R and Y are bonded to M by coordination bonds.PPA complex of this invention may be used for covalently labeling DNA with a complex of the formula (R).sub. 2 --M, wherein R and M are as previously defined. A complex of this invention which contains cobalt may also be used in a method for nicking DNA by effecting single-stranded scission of at least one phosphodiester bond of the DNA with ultraviolet radiation.PPA complex of this invention is further useful in a method for killing tumor cells. A pharmaceutical composition for the treatment of tumor cells in a subject may be prepared containing an effective anti-tumor amount of a complex of this invention and a pharmaceutically acceptable carrier. Such a composition may be used for treating a subject afflicted with tumor cells so as to cause regression of the tumor cells.
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