NEW MATERIAL:The compound of formula I [X is halogen; Y is -NR2- (R2 is H or lower alkyl) or -O-; Z is lower alkylene; l is 0 or 1; R1 is carboxyl, lower alkoxycarbonyl or group of formula II (R3 is cyano; R4 is benzoyloxy, etc.)]. EXAMPLE:dl-5-Bromo-6-(4-carboxy-N-methylanilino)-5-fluoro-5,6-dihydrou racil. USE:A carcinostatic agent. PREPARATION:The compound of formula I can be produced e.g. by reacting a compound of formula III (R5 is lower alkanoyl) with a compound of formula IV in an inert solvent (e.g. ketone, ether, aromatic hydrocarbon, etc.) in the presence of an acid acceptor (e.g. potassium carbonate, pyridine, etc.) at room temperature-80 deg.C for 1-24hr.
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机译：新材料：式I的化合物[X为卤素; Y为-NR 2-（R 2为H或低级烷基）或-O-; Z为低级亚烷基; l是0或1; R 1为羧基，低级烷氧羰基或式II的基团（R 3为氰基; R 4为苯甲酰氧基等）]。实施例：dl-5-溴-6-（4-羧基-N-甲基苯胺基）-5-氟-5,6-二氢尿嘧啶。用途：抗癌剂。制备：可以制备例如式I的化合物。在酸性受体（例如碳酸钾）的存在下，在惰性溶剂（例如酮，醚，芳烃等）中，使式III化合物（R 5为低级烷酰基）与式IV化合物反应吡啶等）在室温-80摄氏度下放置1-24小时。
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