FOERFARANDE FOER FRAMSTAELLNING AV EN STERIL, INJICERBAR, FYSIOLOGISKT GODTAGBAR LOESNING AV ETT ROENTGENKONTRASTMEDEL SAMT EN SOM UTGAONGSMATERIAL ANVAEND LOESNING AV ETT ROENTGENKONTRASTMEDELEL OCH

摘要

Sterile, injectable, physiologically acceptable solutions of an X-ray contrast agent are prepared by autoclaving a solution of a m-carboxamido-o-iodo-N-( beta -hydroxyalkyl)aniline X-ray contrast agent in the presence of a physiologically acceptable buffer system the pH of which decreases with increasing temperature. The presence of a temperature dependent buffer, preferably an amine, enables X-ray contrast agents to be sterilized by autoclaving without significant decomposition. Examples of the autoclaving processes are given and solutions for autoclaving containing a m-carboxamido-o-iodo-N-( beta -hydroxyalkyl)aniline X-ray contrast agent and a physiologically acceptable buffer system the pH of which decreases with increasing temperature are described and claimed.