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method the new therapeutically usable indaani, dihydrobentsofuraani and dihydrobentsotiofeenijohdannaisten preparation
method the new therapeutically usable indaani, dihydrobentsofuraani and dihydrobentsotiofeenijohdannaisten preparation
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机译:新的治疗上可用的茚达尼,二氢苯并呋喃苯胺和二氢苯并噻吩并呋喃苯并噻吩酮制剂的方法
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摘要
Indane-, dihydrobenzofurane-, dihydrobenzothiophene-, and indoline- derivatives of the following formula: CHEM wherein X, R1, R2, R3 and R4 are as defined in Claim 1, are effective at presynaptic DA receptors, or both at pre- and postsynaptic DA receptors, indicating usefulness in the treatment of disorders of the central nervous system (CNS) such as schizophrenia or Parkinson's disease. The 1-aminomethyl derivatives of Formula I exist as optical isomers, and the useful effects are often found in the single enantiomers to a different degree. A method for the preparation of compounds of Formula I is described.
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