framstaellning av 4 - / 4 - / 4 - / 4 - / / 2 - (2,4 - difluorfenyl) - 2 - (1h - azolylmetyl) - 1,3 - dioxolan - 4,5-dihydro-1,3-oxazol-4-yl / metoxi / fenyl / - 1 - piperazinyl / fenyl / triazoloner.

摘要

Novel 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4 -yl] methoxy]phenyl]-1-piperazinyl]phenyl]triazolones of formula CHEM wherein Q is N or CH; R is hydrogen, C1-6alkyl or arylC1-6alkyl; and R1 is hydrogen, C1-6alkyl or arylC1-6alkyl; wherein aryl is phenyl optionally substituted with up to 3 substituents each independently selected from halo, C1-6alkyl, C1-6alkyloxy and trifluoromethyl, the pharmaceutically acceptable acid addition salts and possible stereochemically isomeric forms thereof, which compounds are anti-microbial agents; pharmaceutical compositions containing such compounds as an active ingredient and methods of preparing said compounds and pharmaceutical compositions.