ENCASTING AGENT: A GLYCOPEPTIDER WITH AN ENPHALINIC CHARACTERISTICS, FARING AGENTS FOR THE FRAMEWORK OF ORGANIZATION OF SAOSOM PHARMACEUTICAL PRODUCTS.

摘要

Novel biologically active glycopeptides of the formula Sacch - A - B - R in which Sacch represents a monosaccharide radical in which the OH groups are optionally partially or completely substituted, A represents the radical of a neutral L- or D-amino acid or - if B is absent - represents the radical of a neutral D-amino acid, B is absent or represents the radical of a neutral L- or D-amino acid or an optionally omega -substituted bifunctional acidic or basic L- or D-amino acid and R represents hydroxyl, (C1-C8)-alkoxy, an amine radical which is optionally substituted by one or two identical or different radicals from the series comprising (C1-C8)-alkyl, (C5-C8)-cycloalkyl, (C5-C8)-heteroalkyl or (C5-C8)-heteroaryl, or another acid derivative. These compounds have enkephalinase-inhibiting properties and can therefore be used, for example, as analgesics in human and veterinary medicine. The isolation of these compounds from Streptomyces albus ATCC 21838 and other processes for their preparation are additionally described.