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t - pa mutaterad genom remplacering av i region bestaoende av tre disulfidbindningar (kringle).
t - pa mutaterad genom remplacering av i region bestaoende av tre disulfidbindningar (kringle).
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机译:通过重新定位在由三个二硫键(kringle)组成的区域中使t-pa突变。
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摘要
Tissue plasminogen activator analogs exhibiting greater specificity for fibrin than native t-PA are disclosed. The analogs include the K1 domain of native t-PA replaced with another kringle domain mediating the binding of the analog to fibrin. The kringle contains six cysteine residues. The t-PA analogs may further include a variety of substitutions and modifications. Pharmaceutical compositions containing one or more of the t-PA analogs along with a physiologically acceptable carrier or diluent are also disclosed.
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