首页>
外国专利>
PROCESS FOR PRODUCTION OF THE PIPARASINE-DERIVATIVES OF TEOFILLIN AND TEOBROMIN
PROCESS FOR PRODUCTION OF THE PIPARASINE-DERIVATIVES OF TEOFILLIN AND TEOBROMIN
展开▼
机译:制备替诺菲林和替比林的哌帕西汀衍生物的方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
New compounds of formulas I and II IMAGE (I) IMAGE IMAGE (II) IMAGE and the pharmaceutically acceptable acid addition salts thereof, wherein M is selected from the group consisting of hydrogen, morpholino, benzylamino, di-n-lower alkylamino, n-lower alkylamino and IMAGE wherein Ar is optionally substituted phenyl; Z1 and Z2 are each independently selected from the group consisting of CH2, CHOB and C=O, wherein B is selected from the group consisting of hydrogen and alkanoyl; Y is oxygen or nothing; n is an integer from 0-4 but cannot be zero when Z1 is CHOB; m is an integer from 0-4 but cannot be zero when Z2 is CHOB; R1, R2 and R3 are each independently hydrogen, halogen, hydroxy, trifluoromethyl, alkyl or alkoxy; R4 is lower alkyl; and R5 is hydrogen or lower alkyl, are antihistamines and are therefore useful in the treatment of respiratory diseases including asthma, hay fever, allergies and the common cold. They are also vasodilators.
展开▼
机译:式I和II的新化合物(I)(II)及其药学上可接受的酸加成盐,其中M选自氢,吗啉代,苄氨基,二-n-低级烷基氨基,n-低级烷基氨基和,其中Ar是任选取代的苯基; Z 1和Z 2各自独立地选自CH 2,CHOB和C = O,其中B选自氢和烷酰基; Y是氧或什么都不是; n为0-4的整数,但当Z1为CHOB时不能为零; m是0到4的整数,但是当Z2是CHOB时不能为零。 R1,R2和R3各自独立地为氢,卤素,羟基,三氟甲基,烷基或烷氧基; R4是低级烷基; R 5是氢或低级烷基,是抗组胺药,因此可用于治疗呼吸系统疾病,包括哮喘,花粉症,过敏和普通感冒。它们也是血管扩张剂。
展开▼