首页> 外国专利> 7-(3-ARYL-1-PIPERAZINYL)- AND 7-(3-CYCLOHEXYL-1- PIPERAZINYL)-3-QUINOLONE-CARBOXYLIC ACIDS AND ANTIBACTERIAL COMPOSITIONS CONTAINING SUCH

7-(3-ARYL-1-PIPERAZINYL)- AND 7-(3-CYCLOHEXYL-1- PIPERAZINYL)-3-QUINOLONE-CARBOXYLIC ACIDS AND ANTIBACTERIAL COMPOSITIONS CONTAINING SUCH

机译:7-(3-ARYL-1-哌嗪基)-和7-(3-环己基-1-哌嗪基)-3-喹啉酮羧酸和含此类的抗菌成分

摘要

Novel 1-cyclopropyl-4-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid antibacterials of the formula IMAGE in which R1 is hydrogen, alkyl with 1 to 4 carbon atoms and optionally substituted by hydroxyl, methoxy, amino, dimethylamino, halogen, cyano or alkoxycarbonyl having 1 or 2 carbon atoms in the alkyl moiety, or is oxoalkyl having up to 4 carbon atoms, phenacyl, or acyl having 1 to 4 carbon atoms, phenacyl, or acyl having 1 to 4 carbon atoms, R2 is phenyl or cyclohexyl optionally substituted up to three times by halogen, methyl, phenyl, cyano, hydroxyl, methoxy, benzyloxy, amino, methylamino, dimethylamino, piperidino or nitro, or is methylenedioxyphenyl, methylenedioxycyclohexyl, furyl, tetrahydrofuryl or thienyl, and X1 is hydrogen or fluorine, or pharmaceutically ultizable hydrates, acid addition salts, alkali metal salts or alkaline earth metal salts thereof.
机译:的新型1-环丙基-4-氟-1,4-二氢-4-氧代-7-(1-哌嗪基)-3-喹啉羧酸羧酸抗菌剂,其中R1为氢,烷基为1-4碳原子并任选被烷基部分中具有1个或2个碳原子的羟基,甲氧基,氨基,二甲基氨基,卤素,氰基或烷氧羰基取代,或为具有至多4个碳原子的氧代烷基,苯甲酰基或具有1-4个碳原子的酰基,苯甲酰基或具有1-4个碳原子的酰基,R2是苯基或环己基,可选地被卤素,甲基,苯基,氰基,羟基,甲氧基,苄氧基,氨基,甲氨基,二甲氨基,哌啶子基或硝基最多取代3次。亚甲基二氧基苯基,亚甲基二氧基环己基,呋喃基,四氢呋喃基或噻吩基,且X 1为氢或氟,或其可药用的水合物,酸加成盐,碱金属盐或碱土金属盐。

著录项

  • 公开/公告号NZ212271A

    专利类型

  • 公开/公告日1988-10-28

    原文格式PDF

  • 申请/专利权人 BAYER AG;

    申请/专利号NZ19850212271

  • 申请日1985-05-31

  • 分类号C07D401/02;A61K31/47;A61K31/495;

  • 国家 NZ

  • 入库时间 2022-08-22 06:59:10

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