TREATMENT OF NON-HUMAN MAMMALIAN PEPTIC ULCERS WITH PROSTAGLANDIN COMPOSITIONS

摘要

A composition adapted to be topically applied to a mammal for treating mammalian peptic ulcer disease containing an effective amount of a prostaglandin analog in a pharmacuetical carrier suitable for administration to the skin of the mammal to be treated, said prostaglandin analog having a structure that corresponds to the formula: …CHEM… wherein: R has the formula -CH2- Y - (CH2)2-Z;… -Y- is selected from the group consisting of -(CH2)-3 , cis -HC=CHCH2-, and cis,cis -HC=C=CH-;… -Z is selected from the group consisting of -CH2 OH, and -CO2X, wherein X is hydrogen, a pharmacologically acceptable cation or C1-C6 alkyl;… R1 is n-butyl or phenoxy;… R2 is selected from the group consisting of hydrogen, methyl and hydroxyl;… R3 is selected from the group consisting of hydrogen, methyl and hydroxyl, with the proviso that R2 and R3 cannot both be hydrogen or both be hydroxyl; and… R4 and R5 are the same or different and are selected from the group consisting of hydrogen and hydroxyl, but are not both hydroxyl.