METHOD FOR PREPARING PROLONGED ACUTE IMMUNOTOXINS THAT COMPREHENE A GLYCOPEPTIDIC CONSTITUIN WHICH INACTIVES RIBOSOMES MODIFIED IN THEIR POLYACARACIDITY REASONS

摘要

Prolonged-acting immunotoxin consisting of a conjugate in which an antibody or antibody fragment is coupled, via a covalent structure containing a disulphide group or a thioether group, to a ribosome-inactivating glycoprotein having a prolonged action obtained by oxidation of its saccharide moieties with periodate ions.