water soluble derivative of 1 - (2 - hydroxyethyl) - 2 - methyl - 5 - nitro imidazole therapeutic activity, process for its preparation and related pharmaceutical compositions

摘要

The N-(5-carboxy-5-aminopentan)-carbonic ester of 1-(2-hydroxyethyl)-2-methyl-5-nitro-imidazole is perfectly soluble in water and shows relevant trichomonacide activity. The process for the preparation of the compound of the invention comprises reacting 1-(2-hydroxyethyl)-2-methyl-5-nitro imidazole with an alkyl- or phenyl-chlorocarbonate and hydrolizing the resulting carbonic ester, after isolation, in a water-alcohol medium with lysine hydrochloride. The invention relates furthermore to the pharmaceutical compositions, containing the derivative according to the invention, in form suitable for the several administration routes, in combination with the usual excipients and additives.